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Year : 1991
Tome : 142
Volume : 2
Pages : 115-124
Title : Toxicology of carboxylic ionophore antibiotics in the pig
Authors : A. ANADÔN et M.R MARTINEZ-LARRANAGA.
Summary : The most toxic effects of the carboxylic ionophore reported in the pig have been associated with monensin and salinomycin. The clinical signs of the toxicosis by monensin include anorexia, diarrhea, ataxia, lethargy, dyspnea, myoglobinuria and death. The main clinical-pathological alterations are increases of the serum levels of the enzymes aspartate aminotransferase and creatine kinase which concur with the development of acute necrosis of the skeletal and myocardic muscles. The cardiac lesions are difficult to detect macroscopically. Microscopic examination reveal left auricula myocardia necrosis. Some antibacterial agents induce an increase of the toxicity of ionophores in the pig. It has been shown toxic interaction of tiamulin-monensin, and of tiamulin-salinomycin. The myopathies by ionophores and by combination of ionophores plus tiamulin are considered identical. The treatment of the toxicosis by carboxylic ionophores is mainly symptomatic and protective.
Keywords : Carboxylic ionophore antibiotics - toxicity and mechanism - interactions - pigs
Correspondence : A. ANADÔN
Adress : Département de pharmacologie, Faculté de médecine, Université complutense, 28040 Madrid, Espagne

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