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Year : 1993
Tome : 144
Volume : 3
Pages : 229-233
Title : Local intolerance after intramuscular injection of a long-acting formulation in a cow : clinical biochemistry and ultrasonography
Authors : H.P. LEFEBVRE, J.P. SERTHELON, J.P. FERRE, F. DE LA FARCE et J.P. BRAUN.
Summary : In a cow, the intramuscular injection of a long-acting formulation of chloramphenicol determined local muscle damage evidenced by echography. There was an immediate (from the 10th minute), intense (80 fold peak increase about the 24th hour) and durable (up to the 11th day) increase of plasma creatine kinase activity ; the activities of lactate dehydrogenase and aminotransferases, as well as potassium concentration were also increased.
Keywords : local tolerance - chloramphenicol - creatine kinase - echography - muscle damage - cow.
Correspondence : H.P. LEFEBVRE
Adress : Département de Physiopathologie et Unité Associée INRA Physiopathologie et Toxicologie Expérimentales, École Nationale Vétérinaire, 23, chemin des Capelles, F-31076 Toulouse Cedex.

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