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Year : 1993
Tome : 144
Volume : 6
Pages : 553-557
Title : Immunomodulatory activity of patulin on the functions of dog neutrophilic granulocytes.
Authors : N. DUBECH, J.F. GUELFI et L. ESCOULA.
Summary : Patulin is a mycotoxin present in human and animal food which exert modulatory effects on the functions of dog neutrophilic granulocytes. At concentrations of 0.25-1 µg/ml, it decreases the chemotactic index of cells stimulated by opsonized zymosan. However, when used as chemoattractant at the same concentrations, it favours the migration of the cells. At 1 µg/ml, it inhibits the liberation of superoxyde ions by neutrophils, but it does not modify their ability to phagocyte Saccharomyces cerivisiae, even at concentrations up to 10 µg/ml. These immunosuppressive actions may be explained by a fixation of patulin on sulfhydric groups present on the neutrophil membrane.
Keywords : neutrophilic granulocytes - patulin - immunotoxicology - dog.
Correspondence : N. DUBECH
Adress : Laboratoire de Pharmacologie-Toxicologie, B.P. 3, 180, chemin de Tournefeuille, F-31931 Toulouse Cedex

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