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Year : 1993
Tome : 144
Volume : 12
Pages : 967-974
Title : Eosinophils, IgE and helminthiasis.
Authors : M.T. BAIXENCH et J.F. MAGNAVAL.
Summary : Basically, mammalians' defence against worms lies upon antibodydependent cell cytolysis (ADCC), that involves activated eosinophils and specific immunoglobulins E attached to the targets. Eosinophils are produced by the bone marrow under the regulation of interleukin 5 (IL-5), that also activates them. They are attracted towards the parasites by chemotactic factors, namely helminthic antigens, C5a and eosinophilic chemotactic factor of anaphylaxis that is released by mast cells. Cytotoxic effects are due to the release of cationic proteins from the eosinophil granules. Specific IgE are produced by B cells activated by interleukin 4. IL-4 and IL-5 are secreted by T helpers 2 cells (Th2). The differentiation of this T cell subset is induced by allergens and helminthic antigens. Large amounts of total IgE observed in helminthiasis are due to a non-specific stimulation of B cells, caused by a direct contact between B cells and T cells through CD 23 receptor.
Keywords : eosinophils - IgE - helminthiasis.
Correspondence : M.T. BAIXENCH
Adress : Laboratoirs de parasitologie, CHU Purpan, Place du Dr Baylac, F-31059 Toulouse cedex

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