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Year : 1994
Tome : 145
Volume : 6
Pages : 471-476
Title : The ovariectomized rat as a model for postmenopausal osteoporosis. Therapeutie effects of vitamin D metabolites
Authors : H. BIRNER, R.G. ERBEN and W.A. RAMBECK.
Summary : The changes of bone metabolism in female rats after ovariectomy are similar to the alterations in early postmenopausal women. Vitamin D metabolites, especially the naturally occurring steroid hormone 1,25-dihydroxyvitamin D3, are known to prevent bone resorption, but show negative side effects like hypercalcemia and hypercalciuria. In this study we focused on 1 alpha-hydroxyvitamin D3, on 1 alpha-hydroxyvitamin D2 and on 1,25-dihydroxyvitamin D2. Bilaterally ovariectomized or sham operated female Fischer rats received vitamin D metabolites via their standard laboratory diet starting 2 weeks after surgery. Several times after ovariectomy parameters of bone formation (serum alkaline phosphatase, serum osteocalcin) and bone resorption (urinary hydroxyproline, urinary collagen crosslinks) were measured. 1,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D2 decreased the values for parameters of bone resorption significantly versus the untreated ovariectomized control group. The effect of the corresponding 1 alpha- hydroxyvitamin D metabolites was less distinct, but serum calcium and urinary calcium were lower in the 1 alpha-hydroxyvitamin D groups, especially in the 1 alpha-hydroxyvitamin D2 group. Consequently, the use of the 1 alpha-hydroxyvitamin D2 metabolite in postmenopausal women might represent an alternative treatment with less negative side effects as compared to 1,25-dihydroxyvitamin D metabolites.
Keywords : ovariectomized rats - postmenopausal osteoporosis - vitamin D metabolites - bone marker - collagen crosslinks.
Correspondence : H. BIRNER
Adress : Institute for Physiology, Physiological Chemistry and Nutrition Physiology, Veterinary Faculty, Ludwig-Maximilians-Universitat, Munich, Germany.

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