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Year : 1994
Tome : 145
Volume : 6
Pages : 419-431
Title : Primates monoclonal antibodies : their potential advantages in human therapy.
Authors : A. BLANCHER, F. ROUBINET et P. BÉNARD.
Summary : Mouse or rat monoclonal antibodies have invaded many fields of analytical or research biology, and are now considered as therapeutical tools for the man. Although they have numerous advantages, these heterologous antibodies evoke a humoral response in man leading to the appearance of antibodies which limit their efficacy. Non human primate monoclonal antibodies would be potentialy less immunogenic in man than rodent monoclonals due to the similitude of their structure with that of human antibodies. After a review of the works devoted to the production of non human primates monoclonal antibodies, their advantages and drawbacks are compared to those of chimeric antibodies which result from the humanization of rodent antibodies and to those of human antibodies produced in vivo in mouse either transgenic for human immunoglobulin genes, or grafted with human lymphocytes.
Keywords : monoclonal antibodies - immunoglobulins - primates.
Correspondence : A. BLANCHER
Adress : Laboratoire d'Immunopathologie et Immunothérapie Médicale, CHU Purpan, CRTS, 1, Place du Docteur Baylac, F-31052 Toulouse Cedex

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