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Year : 1999
Tome : 150
Volume : 6
Pages : 543-546
Title : AIterations in blood gas and acid-base status in relationship to porcine stress syndrome (Malignant hyperthermia)
Authors : T.M. GUEORGUIEVA, M.D. PASKALEV, I.P.GUEORGUIEV, G.A. ANGELOV et J. PHILIPOV
Summary : The objective of the study was to investigate the effect of halothane anesthesia on blood gas and acid-base status in stress susceptible (SS) and stress-resistant (SR) pigs. The experiments were conducted on 30 six to ten, weeks old pigs (Large White x Landrace) screened for reactivity to stress by halothane challenge test. Four animals were lothane-positive (experimental group). We have chosen eight from twenty six tested as halothane-negative (control group). Blood samples were collected 8 min after onset of halothane inhalation. The SS pigs showed the following clinical signs: increased body temperature (41.2° C), muscle rigidity, dyspnea, tachypnea and cyanosis. They exhibited significantly lower values of acid-base excess (ABE) and HC03 and had higher H+ concentration and pCO2 than the SR pigs. The results clearly indicated that the development of metabolic acidosis in SS pigs was in association with respiratory acidosis.
Keywords : Acid-base status, stress-susceptibility, pigs
Correspondence : T.M. GUEORGUIEVA
Adress : Department of Biochemistry with principales of clinical biochemistry, Faculty of Veterinary Medecine, Thracian University, 6100 Stara Zagora, Bulgaria

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