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Year : 1996
Tome : 147
Volume : 8-9
Pages : 607-612
Title : Genetic control of experimental autoimmune encephalomyelitis in the rat
Authors : L. DOLBOIS, F. SIMON, M. DELVERDIER, M. AMARDHEIL, F. MASSON, M.B. DELISLE, Ph. DRUET, M. CLANET, N. BOROT et M.P. ROTH
Summary : Experimental autoimmune encephalomyelitis (EAE), a T cell-mediated disease of the central nervous system, is considered as model for multiple sclerosis. The role played by MHC and non-MHC-linked genes in the occurrence of neurological symptoms of EAE, inflammatory infiltrates, and demyelinating lesions, were investigated on 204 (LEW x BN)F2 hybrids. Although the importance of a MHC-linked gene was confirmed, the presence of a RT1 haplotype was not sufficient to induce a strong histological reaction or neurological manifestations. This clearly indicates that other genes are influencing EAE expression.
Keywords : KEY?WORDS : expérimental autoimmune encephalomyelitis ? animal model ? rat ?multiple sclerosis ? genetic control.
Correspondence : Laurence Dolbois
Adress : ENVT, Service de Parasitologie, 23, chemin des Capelles, 31076 Toulouse Cedex; Tel: 05 61 79 38 72

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