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Year : 2008
Tome : 159
Volume : 8-9
Pages : 468-475
Title : Paratuberculosis in sheep: an emerging disease in southern Iran
Authors : A. ORYAN, S. S. SHEKARFOROUSH and A. A. MALAKOOTIKHAH
Summary : Based on gross and histopathologic lesions, paratuberculosis was diagnosed in sheep in Shiraz slaughter house, North of Iran. Ileocecal junction, ileum, jejunum, cecum, colon and associated mesenteric lymph nodes (MLNs) of 5000 carcasses were grossly inspected for wall thickness and/or corrugation of the intestine and enlargement of the associated lymph nodes. Of these, 171 animals showed intestinal thickening and/or corrugation and MLNs enlargement and were suspected to paratuberculosis. However, at histopathological level only six animals exhibited moderate to severe lepromatous or tuberculoid granulomatous enteritis in cecum, colon, jejunum and particularly in the terminal ileum, ileocecal junction and the related lymph nodes. High numbers of acid fast organisms were present in terminal ileum and related MLNs and to a lesser extent in cecum, colon and jejunum. The rectal content of five of them were watery and soft and one of them had normal intestinal contents. The wall of ileum and to a lesser extent cecum, jejunum and colon were thicker and corrugated and the MLNs of ileocecal valve, ileum, jejunum and cecum were larger than normal. The fat deposit surrounding the intestinal wall was either absent or had a jelly shape or liquid appearance. Five sheep showed diffused or lepromatous type granulomatous reactions in their intestine and MLNs with diffused infiltration of lymphocytes, plasma cells, macrophages and rarely giant cells in the lamina propria and submucosa of the intestines and MLNs. The last one had follicular lymphoid infiltrates, with multifocal granulomas in the areas adjacent to payer patches in the ileum and to a lesser extent jejunum and cecum. The ileocecal, jejunal and cecal MLNs of this animal had few focal granulomatous reaction containing acid fast bacilli in the interfollicular areas of cortex and paracortical areas. In a second attempt normal looking samples of intestines and associated lymph nodes of 200 sheep were randomly selected and studied at histipathological level and non of the samples proved to be affected with paratuberculosis. Therefore it could be concluded that Johne's disease might be present in adult sheep having suffered a chronic wasting disease, with or without diarrhea. Consequently, the intestinal tract and mesenteric lymph nodes of these sheep should always be examined at histological level. This is also true even when more evident problems such as caseous lymphadenitis or gastrointestinal parasitism are present.
Keywords : Paratuberculosis, Johne's disease, sheep, histopathology, Iran
Correspondence : A. ORYAN
Adress : Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, IRAN. E-mail : oryan@shirazu.ac.ir
Link : pdf

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