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Year : 2008
Tome : 159
Volume : 8-9
Pages : 444-449
Title : Variations of serum bone alkaline phosphatase activities and osteocalcin concentrations in dogs with experimental osteotomy fixed by two different osteosynthesis techniques
Authors : M. PASKALEV, S. KRASTEV and L. SOTIROV
Summary : In 12 dogs, transperiosteal osteotomies of the right tibia and fibula diaphyses were performed followed by intramedullar osteosynthesis (IMO group, n = 6) or plate osteosynthesis (PLO group, n = 6). Cranio-caudal radiographs were obtained immediately after surgery then on week 2 and every month during 6 months for evaluating bone formation (BF) and bone union (BU). Before surgery and at the same time intervals, blood serum samples were collected for determination of bone alkaline phosphatase (ALP) activities and osteocalcin (OC) concentrations. BF was maximal since the 1st month and stopped at the 4th month in the IMO group whereas it appeared delayed in the PLO group: maximal values were recorded since the 2nd month and BF lasted until the 5th month. The bone union (BU) scores were significantly elevated on month 1 (IMO group: p<0.001 and PLO group: p<0.05) and then markedly increased during the whole period (p<0.001) in the 2 groups. Although not significant, decreases of bone ALP activities compared to presurgery values were more pronounced in the PLO group particularly during the 1st month. By contrast, dramatic increases of serum OC concentrations were observed after intramedullar osteosynthesis during the 1st month whereas this marker was weakly affected by plate osteosynthesis. Consequently, a more intense bone reaction evidenced by radiological signs and by elevation of serum OC concentrations was induced by the intramedullar osteosynthesis.
Keywords : dogs, tibia osteotomy, intramedullar osteosynthesis, plate osteosynthesis, osteogenesis, bone alkaline phosphatase, osteocalcin
Correspondence : M. PASKALEV
Adress : Department of veterinary surgery, Faculty of Veterinary Medicine, 6000 Stara Zagora, BULGARIA. Email: paskalev@uni-sz.bg
Link : pdf

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