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Year : 2017
Tome : 168
Volume : 7-9
Pages : 136-142
Title : The protective effects of nanocurcumin on liver toxicity induced by salinomycin in broiler chickens
Authors : R. SAYRAFI, S.M. HOSSEINI, M.A. AHMADI
Summary : Curcumin, the active principle of turmeric, has been shown to exhibit a wide range of pharmacological activities and has been reported to reduce the toxic effects of certain toxic agents. However, its low absorption, poor solubility and low stability in the body, has curbed its pharmaceutical application. The aim of the present study was to evaluate the possible protective effects of nanocurcumin against salinomycin-induced liver toxicity in broilers. Sixty broiler chicks were randomly divided into 5 groups. Group 1 served as the control while the second group received salinomycin with a daily dosage of 300 mg/kg body weight during a 14-day diet. Groups 3, 4 and 5 were also treated with salinomycin; however, they were orally administered nanocurcumin with daily dosages of 50, 100 and 200 mg/kg body weight, respectively over the same period. At he end of the experiment, blood and tissue samples were collected for biochemical and histological examination. Based on the results, salinomycin significantly (P<0.05) reduced the body weight from 840±43.21 (in control group) to 626±64.31 g, while decreasing the liver weight from 44.52±20.74 (in control group) to 29.42±27.87 g. Also, salinomycin increased the activities of serum aspartate aminotransferase (AST) from 364.80±10.93 to 537.80±40.64 U/L and caused histological alterations in the liver of chicks. Nanocurcumin decreased significantly (P<0.05) the mean serum levels of AST in the 200 mg/kg group (421.5±30.08 U/L) compared to the salinomycin group (537.8±40.64 U/L). In addition, nanocurcumin decreased the incidence and severity of histopathological hepatic lesions, especially in the group 200 mg/kg. The findings of this research indicated that nanocurcumin could protect liver against the toxicity induced by salinomycin.
Keywords : Nanocurcumin, ionophore, hepatoprotection, Histopathology, broilers
Correspondence : R. SAYRAFI
Adress : Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran. reza.sayrafi@gmail.com
Link : pdf

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