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Year : 2014
Tome : 165
Volume : 7-8
Pages : 245-251
Title : Clinical, Blood Biochemical and Hepatic Histological Data in 49 French Scottish Terriers Dogs according to their plasma ALP activity, Hepatic Vacuolation and the presence or absence of Hepatocellular Carcinoma
Authors : C.PEYRON, M.CHEVALLIER, P.LECOINDRE, S.GUERRET, A.PAGNON
Summary : The present study aims at describing the clinical, blood biochemical and hepatic histological features of French Scottish Terrier dogs and finding associations between these different data. Dogs were divided into 3 groups, based on their plasma ALP activity (control, elevated, very elevated). Hepatic biopsies were graded according to their degree of vacuolation, fibrosis, inflammation (activity) and the presence or absence of hepatocellular carcinoma (HCCA). Correlations between clinical, blood biochemical and histological features were examined and comparisons were made with the control group. Forty-nine dogs were included in the study, 18 males and 31 females, with a mean age of 8.3. For most of the dogs, hepatic vacuolation and fibrosis were, respectively, moderate and mild, and inflammation (activity) was low. Plasma ALP activity was significantly associated with hepatic vacuolation (p=0.020). Fibrosis was positively correlated with age, plasma ALT and AST activities. Inflammation was positively correlated with plasma ALT, AST activities and cholesterol. Vacuolation was positively correlated with age, ALT activity and cholesterol. Seventy-five percent of dogs with HCCA had a G3 vacuolation grade, and ALP activity was significantly higher in dogs with HCCA. In the present cohort, elevated plasma ALP activity was associated with hepatic vacuolation and HCCA. Hepatic vacuolation was frequent but moderate (31.9% minimal, 23.4% mild, 23.4% moderate, 10.6% severe). Plasma ALT activity was found to be a good indicator of hepatic vacuolation, fibrosis and inflammation. There is a potential association between hepatic vacuolation and HCCA.
Keywords : Vacuolation, liver, dog, ALP, hepatocellular carcinoma
Correspondence : C.PEYRON
Adress : Clinique Vétérinaire des Cerisioz, Route de Saint Symphorien d?Ozon, 69800 Saint Priest, FRANCE. Email: clemencepeyron@hotmail.fr
Link : pdf

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