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Year : 2007
Tome : 158
Volume : 12
Pages : 607-612
Title : Protective effects of L-carnitine on the hexachlorophene-induced neurotoxicity and oxidative stress in mice
Authors : K. YAPAR, E. ORUC, A. KART AND M. KARAPEHLIVAN
Summary : The aim of this study was to investigate the protective effect of L-carnitine on the hexachlorophene-induced neurotoxicity and lipid peroxidation. Thirty two BALB/c mice were used in this study and were divided into 4 equal groups: animals of the group 1 (control) received daily subcutaneous injections of 0.9 % NaCl for 6 days, animals of the group 2 were treated by L-carnitine (500 mg/kg/day s.c. for 6 days), those of the group 3 received hexachlorophene (126 mg/kg) by gavage and daily injection of 0.9 % NaCl for 6 days and those of the group 4 were treated with L-carnitine plus hexachlorophene. Plasma and brain tissue total sialic acid (TSA), glutathione (GSH), and malondialdehyde (MDA) concentrations were measured 72 hours after the last injection and brain tissue alterations were investigated by conventional histology. Mice treated with hexachlorophene alone (group 3) exhibited higher MDA and TSA concentrations in blood and in brain than those of the 3 other groups whereas plasma and brain GSH concentrations were dramatically depressed. Severe oedema and bleeding were noticed in meninges, cortex, substantia alba and medulla spinalis in this group. By contrast, when animals were exposed to hexachlorophene and L-carnitine, brain injury was markedly reduced. In addition, plasma and brain MDA, TSA and GSH concentrations were significantly modified compared to the group 3. In plasma, the biochemical parameters were similar to values obtained in controls but they remained significantly altered in brain compared to controls. Furthermore, L-carnitine treatment significantly lowered plasma MDAand TSA concentrations and increased GSH concentrations compared to controls. These results evidence the antioxidant properties of L-carnitine and its protective role against the hexachlorophene neurotoxicity and they suggest a beneficial interest of L-carnitine in the treatment of hexachlorophene adverse effects.
Keywords : L-carnitine, hexachlorophene, neurotoxicity, lipid peroxidation, sialic acid, malondialdehyde, glutathione
Correspondence : A. KART
Adress : Department of Pharmacology and Toxicology, College of Veterinary Medicine, University of Kafkas, 36100, Kars, TURKEY. - E-mail: asimkart@yahoo.com - asimkart@hotmail.com
Link : pdf

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