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Year : 2007
Tome : 158
Volume : 8-9
Pages : 452-457
Title : The effect of Maneb on the thyroid and fertility in the rabbit
Authors : MALLEM , KECK.G , FRANCK. M, BOULAKOUD MS
Summary : The aim of the current investigation has been to evaluate the toxic affects of Maneb a dithiocarbamate fungicide on the domestic rabbits. The fungicide was used at four different doses 2, 3, 5, 8 mg/kg body weight. The fungicide was daily administered per os, throughout the five weeks experimental period. Body weight was recorded at 48 hours interval. The results showed the following effects as compared with the control group: a- a remarkable increase of the treated rabbits of the body weight, b- an increase in the plasmatic concentrations of the biochemical parameters: triglycerides, glucose and cholesterol, c- a reduction in the weight of kidneys and testes d- an increase in the weight of the liver e- a highly significant reduction in the number, speed and mobility of spermatozoa accompanied by a significant increase in sperm deformation in the treated groups as compared with the control group.
Keywords : Maneb, toxicity, rabbit, thyroid, spermatozoa
Correspondence : KECK.G
Adress : Ecole Nationale Vtrinaire de Lyon, Dpartement de S.B.F.A Unit des Sciences Pharmaceutiques et toxicologie, 1 avenue Bourgelat, 69280 Marcy lEtoile. FRANCE - E-mail : g.keck@vet-lyon.fr
Link : pdf

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