Website for the Revue de Médecine Vétérinaire

Detail of the article

[Back]

For articles published from January, 2000, you can reach the complete article as a pdf file by clicking on "pdf " in the column "Links" of the table.

Year : 2007
Tome : 158
Volume : 8-9
Pages : 437-441
Title : Variations of biological indicators as highly presumptive markers for fasciolosis in experimentally-infected sheep
Authors : A. MEKROUD, A. CHAUVIN AND D. RONDELAUD
Summary : The aim of this study was to select parameters showing the greatest variations during Fasciola hepatica infections in sheep for establishing high-presumption diagnoses for fasciolosis in Algeria. Eight biological parameters (leukocyte, erythrocyte, eosinophil counts, serum bilirubin, IgG and IgM concentrations and serum enzyme (ALT, AST) activities) were studied in 4-month old female sheep mono-infected (n = 5) with 150 F. hepatica metacercariae and bi-infected (n = 5) (the reinfestation with 150 metacercariae was made 6 weeks later). Erythrocyte counts and serum enzyme (ALT and AST) activities showed insignificant variations in infected sheep compared to uninfected controls (n = 5), whereas significant increases of leukocyte and eosinophil counts were noted in infected sheep. They peaked on the 5th week in both infected groups and also on the 13th week in bi-infected sheep. Bilirubin concentrations significantly increased in the bi-infected group from week 13 to peak at week 15, while insignificant variations in the mono-infected group were found. Significant increases of IgG and IgM levels were also observed in both infected groups. After peaking at weeks 3/5, IgG concentrations remained relatively constant and highly elevated in both groups, while IgM concentrations steadily decreased before another peak at week 11. Because of low costs for measurements of eosinophil counts and bilirubin, such tests may be routinely used to establish high-presumption diagnoses for fasciolosis in Algeria.
Keywords : Fasciola hepatica, Algeria, bilirubin, eosinophils, immunoglobulins, leukocytes, sheep
Correspondence : D. RONDELAUD
Adress : UPRES EA n° 3174 / USC INRA, Faculté de Médecine, 87025 Limoges Cedex, FRANCE - E-mail: daniel.rondelaud@unilim.fr
Link : pdf

[Back]