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Year : 2007
Tome : 158
Volume : 8-9
Pages : 418-424
Title : Clinical effects of Carprofen during experimental bovine pneumonic mannheimiosis
Authors : H. WALLEMACQ, P. BOUTET, L. ZECCHINON, D. DESMECHT, D. BEDORET, E. RAMERY ET P. LEKEUX
Summary : M. haemolytica serotype A1 (formerly known as Pasteurella) is the most important and commonly isolated bacterial pathogen from fatal cases of bovine fibrinous pleuroneumonia. M. haemolytica and its two principal toxins, the lipopolysaccharides (LPS) and the leukotoxin (LktA) induce the recruitment, the activation and the necrosis of neutrophils involved in the pathogenicity of bovine pneumonic mannheimiosis (BPM). The objective of this study was to determine whether systemic therapy with carprofène (Rimadyl®*), a non-steroidal anti-inflammatory drug, improves the disease development in an acute experimental model of BPM. The experimental pathology was induced by trans-tracheal inoculation of M. haemolytica and toxins at T0. One hour post-inoculation, six calves were treated intravenously with carprofen (1,4 mg/kg) while six placebo-treated calves received dose-matched volumes of sterile saline. The clinical and biochemical parameters were measured at one (T+1), three (T+3) and seven (T+7) hours after inoculation. Disease scores for carprofen treated calves were significantly lower than those for placebo-treated controls six hours (T+7) after treatment. These results were associated to a significantly oxygen saturation decrease at T+3 and a significantly blood lactate increase at T+7 in the control calves. Moreover, pulmonary lesions were significantly less extensive than those in the control group. Taken together, this finding suggest that pharmacological modulation by carprofen of pulmonary inflammation after appearance of acute BPM clinical signs leads to calves’ health enhancement and reduces the extent of gross pneumonic lesion.
Keywords : Mannheimia, carprofen, bronchopneumonia, calf, nonsteroidal anti-inflammatory
Correspondence : P. LEKEUX
Adress : Département des sciences fonctionnelles, Faculté de Médicine Vétérinaire, Université de Liège, 20 boulevard de Colonster, B-4000 Liège, BELGIQUE- E-mail : pierre.lekeux@ulg.ac.be
Link : pdf

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