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Year : 2005
Tome : 156
Volume : 1
Pages : 37-42
Title : Pharmacokinetics behaviour of ricobendazole in calves and sheep after its intravenous administration
Authors : E. A. FORMENTINI
Summary : A comparative pharmacokinetic study of ricobendazole (RBZ) after its intravenous administration in calves and sheep was carried out. The drug was administered as 10% solution in DMSO by the left jugular vein in both species. The plasma concentration-time data were analysed using a compartmental approach. A two-compartment open model was selected as the best model able to explain the pharmacokinetic disposition of RBZ in both species. Differences between calves and sheep were encountered in values of the central volume (Vd(c)), the volume at the steady state (Vd(ss)), the volume of area (Vd(area)) and the total clearance (ClB). The first-order rate constants which explain the elimination (k10), distribution (k12) and redistribution (k21) processes estimated by the model did not present differences between species. The fraction of the total amount of drug presented in the organism in the central compartment at the steady state estimated from the mass-transfer first-order rate constant in calves and sheep were almost the same. Moreover, the differences encountered on the Vd(ss) values in both species indicate a major distribution of RBZ in sheep than cattle. Nevertheless, these differences could be not important from a pharmacokinetic or therapeutic point of view. The extraction rate (E) values expressed as the ratio between the ClB and the cardiac output (Q) remained unchanged in calves and sheep and were less than 3% of Q. This gives evidence of the low capacity of the organism of both species to eliminate the drug. In view of these results, it is proposed that the differences on the pharmacokinetic behaviour of RBZ in calves and sheep are not relevant.
Keywords : pharmacokinetics - ricobendazole - calves - sheep
Correspondence : E. A. FORMENTINI
Adress : Ctedra de Farmacologa - Facultad de Ciencias Veterinarias - Universidad Nacional del Litoral RP Kreder 2805, Esperanza (3080) Argentina. e-mail: eforment@fcv.unl.edu.ar
Link : pdf

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