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Year : 2004
Tome : 155
Volume : 7
Pages : 362-370
Title : Systemic mast cell diseases in cats, retrospective study of seven cases, benefits of bone marrow biopsy, comparative aspects.
Authors : D.FRITZ, C.L. HOPFNER and J.C. GUILHOT-CHRÉTIEN.
Summary : Seven cases of systemic mast cell diseases were observed in two male and five female cats. The main clinical signs were poorly specific with lethargy and anorexia, and anemia in five cases. Splenomegaly associated with mast cell invasion was constant (it was observed in 7 cases out of 7). Bone marrow cellularity was markedly increased in three cases, moderately increased in two cases and decreased in two cases. Bone marrow biopsies led to the following diagnoses : myeloproliferative disorder, myelodysplasia, fibrohistiocytic nodular marrow associated with mast cell infiltration, aplastic marrow secondary to mutilating fibrosis, mast cell leukemia. Paratrabecular mast cell infiltration was observed in 3 cases and fibrosis in 4 cases. Only the two cases that did not present fibrosis and concurrent hematologic disorder had a reasonable survival rate when taking into account the nature of the disease.
Keywords : Systemic mast cell disease, myelogram, spleen cytology, bone marrow biopsy, myelofibrosis, myeloproliferative disorder, myelodysplastic syndrome, cat.
Correspondence : Dr. Denis Fritz
Adress : Companion Animal Laboratory (C.A.L), 2, rue des Bas Trévois 10 000 Troyes.
Link : pdf

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