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Year : 2002
Tome : 153
Volume : 6
Pages : 433-436
Title : Tissue residues in rainbow trout dietary exposed to 3h-4n-Nonylphenol
Authors : R. THIBAUT, L. DEBRAUWER and J.P. CRAVEDI
Summary : In order to better assess the risk associated with nonylphenol and the possible consequences for human consumers, we have investigated the identity and kinetics of 4n-nonylphenol (4n-NP) residues in rainbow trout tissues. 48 Hours after oral administration of 3H-4n-NP (100 (g and 925 KBq), radioactivity was widely distributed in tissues but mainly concentrated in the digestive tract, liver, fat, gonads and kidney. At 144h, the substantial amount of radioactivity retained in liver, brain and gonads suggests a possible disruption of the neuroendocrine control of reproduction while the very low levels of NP residues in muscle indicate a limited risk for human consumers. In the liver, the extractable radioactivity (95.7 %) corresponded to 4n-NP (6.3 %) and 4n-NP-glucuronide (83.6 %). In the digestive tract, the extracted radioactivity (64.2 %) contained 4n-NP-glucuronide as major residue, five carboxylic acids detected as such or as glucuronide and sulphate conjugates and unchanged 4n-NP retained in the lipid fraction. Oxidation of the alkyl chain impairs estrogenic activity (unpublished results) but NP and bound residues retained in viscera and adipose tissue are still potential sources of estrogenicity.
Keywords : nonylphenol - residues - trout - metabolism - endocrine disrupters.
Correspondence : R. THIBAUT
Adress : UMR 1089, Laboratoire des Xnobiotiques, INRA, INP-ENSAT, ENVT, B.P. 3, F-31931 Toulouse Cedex 9
Link : pdf

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