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Year : 2002
Tome : 153
Volume : 6
Pages : 419-424
Title : Role of biotransformation in the fate and toxicity of chemicals : consequences for the assessment of residues in fish
Authors : J.P. CRAVEDI
Summary : The purpose of this report is to provide an overview of the metabolism of chemicals in fish, with special reference the identity and fate of residues retained in tissues. The various biotransformation pathways by which lipophilic xenobiotics are converted to hydrophilic metabolites which can be readily excreted are reported. We have attempted to provide a wide range of examples of known bioactivation reactions and the toxicological consequences of their production are evaluated. The target tissues for several compounds are described and the influence of chemical, physiological and environmental factors on their metabolism are discussed. It is concluded that the knowledge of metabolic capacities of fish is a crucial point in assessing the persistence and the toxicity of residues in these species.
Keywords : fish - xenobiotic - metabolism - residues - toxicity.
Correspondence : J.P. CRAVEDI
Adress : UMR 1089 Xénobiotiques, INRA/ENSAT/ENVT, B.P. 3, F-31931 Toulouse Cedex
Link : pdf

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