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| Year : | 2001 |
| Tome : | 152 |
| Volume : | 8-9 |
| Pages : | 597-604 |
| Title : | Preliminary evaluation of the biocompatibility of the small intestinal submucosa (SIS) biomaterial with the rabbit cornea |
| Authors : | F. GRIGUER, I. RAYMOND et A. REGNIER. |
| Summary : | The early stages of the ocular response to porcine small intestinal submucosa (SIS) transplantation were assessed in a model of anterior keratectomy in the rabbit. After surgery, the operated eyes (n = 17) were examined on a regular basis over a 15-day period and animals were sacrified at predetermined times for histopathologic evaluation.In all but one animal, the biomaterial was well tolerated, and the corneal response was restricted to a localized neovascularization. The grafted material was epithelialised within 7 days and incorporated into the corneal tissue without inducing granuloma formation.In one rabbit, the corneal inflammation was severe but the biomaterial was maintained in place.Although further studies with longer follow-up periods are needed, these preliminary observations suggest that porcine SIS can be incorporated into the corneal tissue during healing process and may represent a promising graft material for lamellar keratoplasty. |
| Keywords : | small intestinal submucosa - corneal tolerance - lamellar keratoplasty - rabbit. |
| Correspondence : | A. Regnier |
| Adress : | Clinique d’Ophtalmologie, École Nationale Vétérinaire, 23 chemin des Capelles, F-31076 Toulouse Cedex 03 E-mail : [email protected] |
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