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| Year : | 1995 |
| Tome : | 146 |
| Volume : | 5 |
| Pages : | 309-320 |
| Title : | Antimicrobial chemotherapy : new considerations and their applications to veterinary medicine. |
| Authors : | G. KECK et PM. BORNE |
| Summary : | Relations between pharmacokinetics, antimicrobial activity, and distribution and maintenance should be studied in order to specify most effective posology schemes. Some antimicrobials are concentration-dependant : their bactericidal speed increases with concentration. Others are time-dependant : their bactericidal activity reaches its maximum level when MIC is obtained, and is then directly related to exposure time. The post-antibiotic effect depends on the antimicrobial and the pathogen considered, and can be measured in experimental models. Practical consequences for antimicrobial prescribing are currently discussed, especially for bactericidal antimicrobials and taking into account toxicity and clinical data. |
| Keywords : | killing curves - post-antibiotic effect - dose-dependent - time-dependent - antibiotic. |
| Correspondence : | G. KECK |
| Adress : | Département des Sciences Biologiques, E.NVL.-F-69280 Marcy l'Étoile |
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