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Year :	1995
Tome :	146
Volume :	11
Pages :	723-730
Title :	P-Glycoprotein : physiological role and implication in oncology.
Authors :	J. D. BAILLY, G. LAURENT et M. DELVERDIER.
Summary :	The MDR phenotype seems to play an important role in the resistance of neoplastic cells to anticancer drugs. This phenotype is associated with overexpression of a 170 kDa membrane protein called P-glycoprotein (P-gp). This protein is considered to be a transporter wich pumps anti-tumor agents outside of the cells. P-gp is constitutively expressed in several normal tissues suggesting an important role in protection and/or detoxification. This protein is also frequently overexpressed in chemoresistant epithelial and hematological tumors. The discovery of the MDR phenotype led to the identification of agents wich are able to reverse this resistance. These molecules, selected on their capacity to inhibe P-gp function are, usually too toxic to be used in vivo .
Keywords :	P-glycoprotein - MDR phenotype - chemoresistance - physiological role - chemosensitization.
Correspondence :	J. D. BAILLY
Adress :	CNRS, Laboratoire de Pharmacologie et de Toxicologie fondamentales, Centre Cladius Régaud, 20-24, rue du Pont St-Pierre, F-31000 Toulouse et École Nationale Vétérinaire de Toulouse, 23, chemin des Capelles, F-31076 Toulouse Cedex