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Year :	2011
Tome :	162
Volume :	12
Pages :	574-579
Title :	Functional and morphological state of the liver in Simmental dairy cows during transi- tional period
Authors :	R. DJOKOVIC, Z. ILIC, V. KURCUBIC, M. PETROVIC, V. DOSKOVIC
Summary :	The objective of the present study was to determine morphological and func- tional state of the liver in healthy late pregnant (n = 15) and puerperal (n = 15) Simmental dairy cows belonging to the same farm. Liver lipid contents were determined on tissue sections stained with Sudan III from percutaneous biopsies and various blood metabolites and serum enzyme activities were determined by photometric methods. In cows in early lactation, a significantly higher liver steatosis than in late pregnant females was observed, although it was re- mained mild. This liver injury was positively coupled to lipomobilisation as proved by significant increases in serum β-hydroxybutyrate and free fatty acid concentrations, to cell damage as evidenced by significant increases in the bilirubin concentrations and in the serum AST (aspartate aminotransfe- rase), GGT (?-glutamyl transferase) and LDH (lactate dehydrogenase) acti- vities but the fatty infiltration has also induced the reduction of the hepatocyte syntheses as reflected by significant decreases in circulating concentrations of triglycerides, glucose and albumin. However, values of the altered bioche- mical markers in puerperal cows have stayed within the physiological limits. These results demonstrate that mild fatty liver physiologically occurred during post-partum inducing some cellular lesions and a weak function impairment of the liver.
Keywords :	Dairy cows, transition period, late pregnancy, early lactation, liver, lipomobilisation, steatosis, blood bio- chemistry, enzymes
Correspondence :	R. DJOKOVIC
Adress :	Department of Animal Science, Faculty of Agronomy- ?a?ak, University of Kragujevac, Cara Du?ana 34, 32000 ?a?ak, SERBIA - Corresponding author: [email protected]
Link :	pdf

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