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| Year : | 2015 |
| Tome : | 166 |
| Volume : | 1-2 |
| Pages : | 11-19 |
| Title : | Ameliorative effect of extra virgin olive oil on hexavalent chromium-induced nephrotoxicity and genotoxicity in rats |
| Authors : | T. M. SABER, M. R. FARAG, R.G. COOPER |
| Summary : | This study investigated the ameliorating effect of extra virgin olive oil (EVOO) on hexavalent chromium [Cr (VI)]-induced nephrotoxicity and genotoxicity in rats. Twenty-four male Sprague-Dawley rats were divided into four groups of six animals (n= 6/group): group I served as a control, group II received oral Cr (VI) at a dose of 6.25 mg/Kg body weight (BW), group III was co-treated with 6.25 mg/Kg BW Cr (VI) and 1.5 ml/Kg BW EVOO, and group IV was orally administered EVOO (1.5 ml/Kg BW) three times a week for 4 weeks. The results showed that Cr (VI) significantly (p<0.05) increased the levels of serum urea, creatinine, total protein, and albumin; the albumin/globulin (A/G) ratio; and the renal malondialdehyde (MDA) concentration. In addition, Cr (VI) significantly decreased catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels when compared with the control group. Cr (VI)-treated rats showed a significant increase in all parameters of kidney DNA damage using a comet assay. Co-treatment with EVOO ameliorated all of the Cr (VI)-induced responses listed above. These results were corroborated with histopathological ?ndings. The present study suggests that EVOO is effective at ameliorating some of the kidney and DNA damage induced by Cr (VI) toxicity. Further studies are needed to evaluate this ameliorative effect of EVOO on other environmental pollutants. |
| Keywords : | Hexavalent chromium, Antioxidant, Nephrotoxicity, Genotoxicity, Extra virgin olive oil |
| Correspondence : | T. M. SABER |
| Adress : | Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. [email protected] |
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