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Year :	2013
Tome :	164
Volume :	3
Pages :	156-161
Title :	Plasma C-reactive protein concentration in dogs with experimentally-induced Staphylococcus aureus infection
Authors :	T. M. GEORGIEVA, D. ZAPRYANOVA, I. NIKIFOROV, S.A. DENEV
Summary :	The aim of the present study was to evaluate the C-reactive protein (CRP) concentration in dogs with experimentally-induced Staphylococcus aureus infection. For that, bacterial suspension (5 mL, density: 3.1x109 c.f.u./mL) was subcutaneously applied to 9 mongrel, 2 years old, male dogs whereas 6 other dogs served as negative controls and plasma CRP concentrations were determined using a species-specific commercial ELISA kit before application (t = 0 hour), 6, 24, 48 and 72 hours and 7, 14 and 21 days later. Plasma CRP concentrations were significantly higher in infected dogs than in the controls since the 6th hour and for the whole experimental period. Furthermore, this marker significantly peaked on days 1 and 7. In parallel, systemic and local clinical signs gradually developed during the first 48 hours and marked increases in CRP concentrations on day 1 were associated with severe clinical symptoms while the second peak of CRP concentrations (on day 7) was not coupled to clinical signs. These results indicated that plasma CRP concentrations increased in early stage of Staphylococcus infection and could be used as a helpful indicator for an early diagnostic in dogs.
Keywords :	dog, C-reactive protein, Staphylococcus aureus, clinical signs, acute phase response, positive acute phase protein
Correspondence :	D. ZAPRYANOVA
Adress :	Department of Pharmacology, Veterinary Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, BULGARIA. Email: [email protected]
Link :	pdf

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