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Year : 2005
Tome : 156
Volume : 11
Pages : 569-573
Title : Influence of bivalent vaccine Miloxan (Clostridium perfringens type C,D and Clostridium oedematiens type B) and the C3 genotypes on lysozyme and complement concentrations in dairy sheep
Authors : L. SOTIROV, I. DIMITROV, M. DJORBINEVA, S. TANCHEV AND B. BIVOLARSKI
Summary : The aim of this experiment was to study the influence of vaccination against Clostridium perfringens type C,D and Clostridium oedematiens type B and the C3 genotypes in dairy sheep on lysozyme and alternative pathway of complement activation (APCA) concentrations. Thirty-four dairy sheep [Stara Zagora x East-Friesian and (Stara Zagora x East-Friesian) x Blackhead Pleven breeds], were used belonging to the four principal genotypes: FS genotype (10 sheep), FF genotype (5 sheep), SS genotype (10 sheep) and F7S genotype (9 sheep). The animals were vaccinated with Bulgarian bivalent vaccine Miloxan (Clostridium perfringens type C,D and Clostridium oedematiens type B) after a baseline blood sampling for the determination of their immune status. The second analysis was performed 21 days after. Prior to the vaccination, the lysozyme concentrations and APCA activity between the C3 genotypes were not significantly different. After the vaccination, the lysozyme concentrations were increased, particularly for the SS genotype compared to the FS genotype (p<0.05). In the same way, vaccination induced increases of APCA values exempt for the SS genotype sheep. Maximal APCA values were observed in the SS genotype before vaccination, whereas following the vaccination, the FF genotype sheep presented maximal APCA activities, and the post vaccination APCA in the FF genotype was higher than the prevaccination APCA in the SS genotype (p<0.05). The vaccination against above bacteria and the C3 genotype affiliation influenced significantly lysozyme concentrations and the alternative pathway of complement activation in sheep.
Keywords : lysozyme - complement - sheep - vaccination
Correspondence : L. SOTIROV
Adress : Department of Genetics ; Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.
Link : pdf

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